micronized estradiol造句

• Oral micronized estradiol was first approved in the United States under the brand name Estrace in 1975.
• Micronized estradiol, which allowed estradiol to be taken by mouth, was not introduced until 1975.
• Orally, EE is about 100 times as potent by weight as natural estrogens like micronized estradiol and conjugated equine estrogens.
• These concentrations of estradiol and estrone are comparable to those observed with 1 and 2 mg / day oral micronized estradiol.
• Micronized estradiol, via the oral route, was first evaluated in 1972, and this was followed by the evaluation of vaginal and intranasal micronized estradiol in 1977.
• Micronized estradiol, via the oral route, was first evaluated in 1972, and this was followed by the evaluation of vaginal and intranasal micronized estradiol in 1977.
• It is approximately twice as potent as micronized estradiol orally and has a comparatively reduced impact on liver parameters such as changes in sex hormone-binding globulin production.
• Upon sublingual ingestion, a single 0.25 mg tablet of micronized estradiol has been found to produce peak levels of 300 pg / mL estradiol and 60 pg / mL estrone within 1 hour.
• Vaginal micronized estradiol achieves a far higher estradiol-to-estrone ratio in comparison to oral estradiol, with a daily dosage of 0.5 mg resulting in estradiol and estrone levels of 250 pg / mL and 130 pg / mL, respectively.
• A dosage of 1 mg / day oral micronized estradiol results in circulating concentrations of 30 50 pg / mL estradiol and 150 300 pg / mL estrone, while a dosage of 2 mg / day produces circulating levels of 50 180 pg / mL estradiol and 300 850 pg / mL estrone.